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本文研究[~3H]标记的黄花夹竹桃次甙乙(Neriifolin简称次甙乙)在大鼠体内的药代动力学。静脉注射后[~3H]-次甙乙在血浆中的消除半衰期(T_(1/2)β)为5天,分布容积(Vd)为15.3L/kg。药物的主要分布在肝脏、胆汁和胃肠道内。灌胃给药吸收迅速完全,30 min血药浓度即达高峰。无论静脉注射或灌胃后,放射性主要从粪中排出,尿中较少,排出形式主要是代谢产物。[~3H]-次甙乙与血浆蛋白的结合为91.7%。结果表明:次甙乙在大鼠体内的药代动力学特点与一般亲脂性强心甙相似。
This article studies the pharmacokinetics of [~ 3H] -labeled Neriifolin B in rats. The half-life of elimination of [~ 3H] -glycoside B in plasma after intravenous injection (T 1/2 (β)) was 5 days and the volume of distribution (Vd) was 15.3 L / kg. The main distribution of drugs in the liver, bile and gastrointestinal tract. Absorption of oral administration quickly and completely, 30 min plasma concentration reached the peak. Regardless of intravenous or intragastric administration, the radioactivity is mainly excreted in the feces, less in the urine and the predominant form of excreted metabolites. [~ 3H] -glycoside B and plasma protein binding was 91.7%. The results showed that the pharmacokinetics of Glycosides B in rats were similar to those of lipophilic cardiac glycosides.