Low Levels of Complement Factor C4 Not Always Implicate Disease Activity in Systemic Lupus Erythemat

• 作 者: E. J. ter Borg H. van Velzen-B
• 机 构: DepartmentofClinicalImmunology,DepartmentofImmunopathologyandBloodCoagulation,DepartmentofInternalMe
• 出 处: 临床医学国际期刊(英文)
• 发表日期: 2013年2期
• 关键词: COMPLEMENT HOMOZYGOUS C4A ISOTYPE Deficiency Systemic LUPUS ERYTHEMATOSUS Comple

A lupus patient with a clinically quiescent disease stage will be described who had severely depressed C4 levels while levels of C3 en CH50 were normal. Additional testing revealed a homozygous C4Aisotype deficiency as the cause of the very low C4 levels.