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特发性血小板减少性紫癜(ITP)病因不明,循环血小板抗体与血小板破坏亢进有关,其抗体主要是IgG。但用通常方法测得正常人也有大量的血小板结合IgG,其它一些血小板减少症亦有明显增高者,故对于ITP的诊断帮助很小,甚至有人认为它是与ITP的病理生理无关的非特异性蛋白。作者使用抗人IgG Fc片段的小鼠单克隆抗体分析法,对54例血小板减少患者与48名正常人进行了研究。Ⅰ组是免疫相关的血小板减少症17例,Ⅱ组是对治疗抵抗的ITP11例,Ⅲ组为不需治疗的慢性稳定型血小板减少症6例,Ⅳ组系非免疫性血小板减少症20
Idiopathic thrombocytopenic purpura (ITP) etiology is unknown, circulating platelet antibodies and hyperthyroidism related to the destruction of its antibody is mainly IgG. However, in normal methods, normal people also have a large number of platelet-bound IgG, and some other thrombocytopenia are also significantly higher, so the diagnosis of ITP is very small. Some people even consider it as a non-specific protein that is not related to the pathophysiology of ITP . The authors used a mouse monoclonal antibody assay against the anti-human IgG Fc fragment to study 54 patients with thrombocytopenia and 48 normal controls. Group Ⅰ was immune-related thrombocytopenia in 17 cases, group Ⅱ was treatment-resistant ITP in 11 cases, group Ⅲ was untreated chronic stable thrombocytopenia in 6 cases, and group Ⅳ non-immune thrombocytopenia in 20