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巴马亭(Palmatine)是一种生物碱,其化学结构与延胡索乙素及小蘖碱相似.作者在研究巴马亭等药物对大鼠ACTH分泌活动的影响时,观察到大鼠于皮下注射巴马亭约半小时后,动物的嘴鼻部及四肢出现明显的浮肿.为了解巴马亭的致浮肿作用及此作用的性质,我们作了下列的研究.结果与讨论所用动物为体重100-150克的雄性大鼠.用微分卡尺量大鼠的一侧后爪的厚度.以给药前与给药后后爪厚度相差的毫米数,作为判定浮肿形成的程度的指标.(一)大鼠对注射巴马亭的类过敏反应
Palmatine is an alkaloid whose chemical structure resembles that of tetrahydropalmatine and berberine. When the authors investigated the effects of drugs such as parmatide on ACTH secretion in rats, it was observed that rats were injected subcutaneously Approximately half an hour after Pama Pavilion, there was a marked edema on the mouth, nose, and extremities of animals, and in order to understand the edema effect of Parmesan and the nature of this effect, we made the following studies: Results and Discussion Animals used were body weight 100 -150 g of male rats.A differential caliper was used to measure the thickness of the rat’s hind paws, which was determined by the number of millimeters between the pre-administration and post-administration humor thickness to determine the degree of edema formation. Anaphylaxis in rats on parmesan injection