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伴嗜酸细胞增多的甲状腺硬化性黏液表皮样癌是一种罕见的、发病机制不明的甲状腺肿瘤,类似于涎腺的黏液表皮样癌。为提高对该肿瘤的认识,作者回顾性分析9例患者的临床病理资料,应用二代测序及荧光原位杂交技术分析其分子特征,并复习相关文献。9例患者中男性3例,女性6例,年龄30~77岁,中位年龄59岁,其中5例临床表现为甲状腺无痛性肿块,2例伴甲状腺乳头状癌,1例有乳头状癌病史。肿瘤大体呈灰白或黄
Eosinophilic thyroid sclerosis mucoepidermoid carcinoma is a rare, unidentified thyroid tumor similar to the mucoepidermoid carcinoma of the salivary gland. To improve the understanding of the tumor, the authors retrospectively analyzed the clinicopathological data of nine patients. The molecular characteristics were analyzed by second-generation sequencing and fluorescence in situ hybridization, and the related literatures were reviewed. Nine patients included 3 males and 6 females, ranging in age from 30 to 77 years with a median age of 59 years. Of the 9 patients, 5 had clinically painless masses of the thyroid, 2 had papillary thyroid carcinoma, and 1 had papillary carcinoma Medical history. Tumor is generally gray or yellow