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目的检测特发性血小板减少性紫癜(ITP)患者T淋巴细胞亚群及NK细胞的变化,探讨其在ITP发病机制中的作用。方法应用流式细胞术分别检测80例ITP及35例正常对照组T淋巴细胞亚群、NK细胞变化。结果 ITP患者CD3+、CD4+细胞百分比及CD4+/CD8+比值明显低于正常对照组(P<0.01),CD8+细胞百分比高于正常对照组(P<0.01)。NK细胞百分比明显低于正常对照组P<0.01)。结论及T淋巴细胞亚群及NK细胞的变化可较好的反映ITP的病理过程,对提高ITP的诊断水平及指导临床具有一定的使用价值。
Objective To detect the changes of T lymphocyte subsets and NK cells in patients with idiopathic thrombocytopenic purpura (ITP) and to explore their roles in the pathogenesis of ITP. Methods Flow cytometry was used to detect T lymphocyte subsets and NK cells in 80 cases of ITP and 35 cases of normal control group respectively. Results The percentage of CD3 +, CD4 + cells and CD4 + / CD8 + in ITP patients were significantly lower than those in normal controls (P <0.01). The percentage of CD8 + cells in ITP patients was higher than that in normal controls (P <0.01). NK cell percentage was significantly lower than the normal control group P <0.01). Conclusion The changes of T lymphocyte subsets and NK cells can better reflect the pathological process of ITP, and have certain value in the diagnosis of ITP and clinical guidance.