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为了解老年及青年人大肠癌组织嗜铬蛋白Ａ（ＣｈｒｏｍｏｇｒａｎｉｎＡ，ＣＧＡ）和Ｐ５３蛋白聚集变化特征及意义。采用免疫组织化学ＡＢＣ法，检测术前未经化疗和放疗的２５例老年（≥６０岁）及１５例青年人（≤４０岁）大肠癌患者癌组织中ＣＧＡ及Ｐ５３蛋白的变化。结果：老年组患者ＣＧＡ阳性表达５例，占２０％，青年组患者阳性表达１０例，占６７％，老年组ＣＧＡ阳性表达率明显低于青年组（Ｐ＜０．００５，χ２检验）；Ｐ５３免疫阳性细胞定量分析发现：老年组患者癌组织切片Ｐ５３阳性细胞数为（６６２±５６８）ｍｍ－２，青年组为（１２０８±７６１）ｍｍ－２，老年组明显低于青年组（Ｐ＜０．０５）。提示：青年和老年大肠癌可能有不同的发病学基础，这种不同的发病学基础是影响其临床特征的重要因素之一。
To understand the characteristics and significance of changes in chromogranin A (CGA) and P53 protein in colorectal cancer in elderly and young adults. Immunohistochemical ABC method was used to detect the changes of CGA and P53 protein in the tissues of 25 patients (≥60 years old) and 15 young people (≤40 years) with colorectal cancer before chemotherapy without chemotherapy and radiotherapy. Results: The CGA positive expression in elderly patients was 5 cases, accounting for 20%. The positive expression of CGA in youth group was 10 cases, accounting for 67%. The positive rate of CGA in old age group was significantly lower than that in young group (P<0.005, χ2 test); P53 Quantitative analysis of immunopositive cells revealed that the number of P53 positive cells in the elderly patients was (662±568) mm-2, and that of the young patients was (1208±761) mm-2. The elderly patients were significantly lower than the young patients (P<0). .05). Tip: Young and elderly colorectal cancer may have different pathogenesis, and this different pathogenesis is one of the important factors affecting their clinical characteristics.