论文部分内容阅读
目的探讨宫腔镜结合C-erbB-2、nm23及ER表达在子宫内膜癌中的诊断意义。方法宫腔镜检查2400例患者,对筛查出的35例子宫内膜癌、10例内膜不典型增生及10例正常内膜,用免疫组化SP法检测C-erbB-2、nm23和ER表达。结果C-erbB-2、nm23、ER阳性表达率依次为74.29%、51.43%、54.29%;50%、30%、60%;30%、10%、90%。三者nm23、ER阳性表达率明显升高,差异有显著性(P<0.05);C-erbB-2阳性表达率明显降低,差异有显著性(P<0.05)。宫腔镜定位活检确诊子宫内膜癌35例(35/2400),占1.46%。结论宫腔镜直观病灶,结合C-erbB-2、nm23及ER表达对内膜癌早期诊断有意义。
Objective To investigate the diagnostic value of hysteroscopy combined with C-erbB-2, nm23 and ER expression in endometrial carcinoma. Methods Hysteroscopy was performed in 2,400 patients. 35 cases of endometrial carcinoma, 10 cases of atypical hyperplasia and 10 cases of normal endometrium were screened. Immunohistochemical SP method was used to detect the expression of C-erbB-2, nm23 and ER expression. Results The positive rates of C-erbB-2, nm23 and ER were 74.29%, 51.43%, 54.29%, 50%, 30%, 60%, 30%, 10% and 90%, respectively. The positive rates of nm23 and ER in the three groups were significantly higher (P <0.05), the positive rate of C-erbB-2 was significantly lower (P <0.05). Hysteroscopic biopsy confirmed 35 cases of endometrial cancer (35/2400), accounting for 1.46%. Conclusion Hysteroscopic visual lesions, combined with the expression of C-erbB-2, nm23 and ER, have an important significance in the early diagnosis of endometrial cancer.