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目的:研究舌鳞癌组织中细胞外基质金属蛋白酶诱导因子(EMMPRIN)的表达及其与舌癌患者临床病理特征和生存期之间的相关性。方法:应用SP免疫组织化学法,检测68例舌鳞癌组织及相应的癌旁组织中EMMPRIN的表达情况,并对68例舌鳞癌患者进行随访观察。应用非参数秩和检验检测两个独立样本的EMMPRIN的表达差异,应用SPSS 13.0软件包进行生存分析;应用Cox比例风险模型分析预后。结果:EMMPRIN在舌鳞癌组织中的表达阳性率高于相应的癌旁组织(P<0.05)。舌鳞癌组织中EMMPRIN的表达与肿瘤大小和临床分期密切相关,与性别、年龄、淋巴结转移和肿瘤病理分化程度不相关。Cox比例风险模型多因素预后分析显示,EMMPRIN表达是影响舌鳞癌患者预后的独立因素。结论:EMMPRIN可以作为舌鳞癌预后判断的参考指标,并有望成为口腔癌生物治疗的潜在靶点。
Objective: To study the expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in tongue squamous cell carcinoma and its correlation with clinicopathological features and survival of tongue cancer patients. Methods: Immunohistochemical SP method was used to detect the expression of EMMPRIN in 68 cases of tongue squamous cell carcinoma and its corresponding paracancerous tissues, and 68 cases of tongue squamous cell carcinoma were followed up. Non-parametric rank sum test was used to detect the difference of EMMPRIN expression between two independent samples. Survival analysis was performed using SPSS 13.0 software package. Cox proportional hazards model was used to analyze the prognosis. Results: The positive rate of EMMPRIN in tongue squamous cell carcinoma was higher than that in corresponding adjacent tissues (P <0.05). The expression of EMMPRIN in TSCC is closely related to tumor size and clinical stage, but not to sex, age, lymph node metastasis and tumor pathological differentiation. Cox proportional hazard model multivariate prognostic analysis showed that EMMPRIN expression is an independent factor affecting the prognosis of patients with tongue squamous cell carcinoma. Conclusion: EMMPRIN can be used as a reference index for prognosis of tongue squamous cell carcinoma and is expected to be a potential target for oral cancer biological therapy.