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脑膜白血病一般采用甲氨喋呤鞘内给药或脑外局部照射治疗,但疗效差且对脊髓或脑损伤的危险性大,所以要寻找其他药物或治疗办法。 2,4二氨嘧啶类药物是50年代合成的抗疟叶酸拮抗剂,其中2,4-二氨5-(3,′4′-二氯苯基)-6甲基嘧啶(DMP)曾试用于治疗白血病。1954年治疗12例急性淋巴白血病儿童,其中3例缓解,但因每天给药毒性非常大,故遭废弃而改用甲氨喋呤。 1971年有人报导,口服抗疟药乙胺嘧啶因易进入中枢神经系统而成功地治疗了两例脑膜白血病病人,这促进了对DMP重新研究,因口服DMP也很易进入中枢神经组织。
Meningchic leukemia generally use methotrexate intrathecal administration or extracerebral irradiation, but poor efficacy and the risk of spinal cord or brain injury, so look for other drugs or treatment. 2,4-diaminopyrimidines are anti-malarial folic acid antagonists synthesized in the 1950s. Among them 2,4-diamino 5- (3 ’, 4’-dichlorophenyl) -6-methylpyrimidine In the treatment of leukemia. In 1954, 12 children with acute lymphoblastic leukemia were treated, 3 of whom were relieved. However, due to the very large toxicity of daily administration, methotrexate was discarded instead. It was reported in 1971 that two oral meningococcal patients were successfully treated with oral antimalarial pyrimethamine for ease of entry into the central nervous system, which facilitated a re-study of DMP because oral administration of DMP is also very accessible to the central nervous system.