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目的 利用飞行模拟器评价短效类催眠药三唑仑和速可眠对模拟飞行工作能力的影响。 方法 ４ 名健康青年男性志愿者，连续３ 周模拟飞行试验，每周一次。受试者于中午１２：００ 分别交叉服用三唑仑（０．２５ ｍ ｇ），速可眠（１００ ｍ ｇ）和安慰剂后，在噪声干扰下睡眠５ ｈ，分别于用药后８ ｈ、１０ ｈ、１２ ｈ 和２１ ｈ 在飞行模拟器上检测模拟飞行能力，并记录模拟飞行中心率和受试者对完成飞行任务的主观评价。 结果 用药前和用药后８ ｈ、１０ ｈ、１２ ｈ、２１ ｈ 的模拟飞行工作能力变化和两种催眠药三唑仑和速可眠对模拟飞行中的心率变化及完成模拟飞行任务的主观评价均无明显差异。 结论 服用短效类催眠药三唑仑和速可眠诱导睡眠，用药后８ ｈ 对模拟飞行工作能力未见明显副作用
Objective To evaluate the effects of short-acting hypnotics such as triazolam and siberian on the ability of simulated flight using flight simulator. METHODS: Four healthy young male volunteers were enrolled in a simulated flight test three weeks in a row. Subjects were randomized to receive either triazolam (0.25 m g), placebo (100 m g) and placebo at 12:00 noon, and then allowed to sleep for 5 hours under noisy disturbance. After 8 h, 10 h, 12 h and 21 h were used to test the simulated flight capability on the flight simulator. The simulated flight center rate and subjective evaluation of the completed mission were recorded. Results The changes of simulated flight ability and the subjective evaluation of heart rate of simulated flight and the two hypnotics, Triazolam and Suopyram, before and 8 h, 10 h, 12 h and 21 h after drug administration No significant difference. Conclusions Taking short-acting hypnotics such as triazolam and somnolence-inducing sleep, no obvious side effects were observed after 8 h