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目的:探讨常州地区农村人群糖尿病相关危险因素,为采取相应的干预措施提供参考依据。方法:采用多阶段整群抽样的方法,于2004年6月-2005年9月在常州市武进区共抽取20 803例居民进行了基线调查,并在2008年3月-2009年10月成功随访18 838例。采用巢式病例对照研究,将本次随访新发101例糖尿病患者作为病例组,按照1∶4频数匹配,随机抽取404例年龄性别完全匹配且基线未患糖尿病的对象作为对照,采用单因素和多因素Logistic回归分析糖尿病的相关危险因素。结果:多因素Logistic回归结果显示,高血压、超重(BMI 24.00-27.99)、肥胖(BMI≥28)可增加糖尿病的发病风险,而高密度脂蛋白可降低糖尿病的发病风险。结论:高血压、超重(BMI 24.00-27.99)与肥胖(BMI≥28)以及较低的高密度脂蛋白可能是常州农村地区糖尿病发病的危险因素,应当针对重点人群干预降低糖尿病发病风险。
Objective: To investigate the risk factors related to diabetes in rural population in Changzhou, and to provide reference for the corresponding interventions. Methods: A total of 20 803 residents were sampled in Wujin District of Changzhou City from June 2004 to September 2005 for the baseline survey by multi-stage cluster sampling and were followed up successfully from March 2008 to October 2009 18 838 cases. Using a nested case-control study, 101 newly diagnosed diabetic patients at this follow-up were selected as the case group. 404 patients of complete age and sex matched with no diabetes at baseline were randomly selected according to the 1: 4 frequency matching. Multivariate logistic regression analysis of diabetes related risk factors. Results: Multivariate Logistic regression showed that hypertension, overweight (BMI 24.00-27.99), and obesity (BMI≥28) increased the risk of diabetes, while high density lipoprotein could reduce the risk of diabetes. Conclusions: Hypertension, overweight (BMI 24.00-27.99) and obesity (BMI≥28) and lower HDL may be the risk factors of diabetes in rural areas of Changzhou. The intervention of key population should reduce the risk of diabetes.