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肿瘤相关巨噬细胞(tumor-associated macrophage,TAM)是肿瘤微环境中的一种重要的炎症细胞。活化后的TAM通过分泌多种细胞因子和趋化因子促进肿瘤相关的血管生成、侵袭、浸润和转移;该过程也是免疫调控中的重要环节,TAM中核转录因子-κB(nuclear transcription factor-κB,NF-κB)、Toll样受体(Toll like receptor,TLR)等介导的信号通路的活化可以促进肿瘤的生长与增殖。上述功能受TAM所处肿瘤微环境的影响。对多种人类实体瘤和血液系统恶性肿瘤的研究发现,TAM与肿瘤预后不良相关。TAM向肿瘤组织的归巢能力使针对TAM的分子靶向治疗为肿瘤诊疗开辟了新思路,是抗肿瘤治疗的有效手段。
Tumor-associated macrophage (TAM) is an important inflammatory cell in the tumor microenvironment. The activated TAM promotes tumor-related angiogenesis, invasion, invasion and metastasis through the secretion of various cytokines and chemokines; this process is also an important part of immune regulation. TAM transcription of nuclear transcription factor-κB (nuclear transcription factor-κB, Activation of NF-κB, Toll-like receptor (TLR) and other signaling pathways can promote tumor growth and proliferation. The above functions are affected by the tumor microenvironment in which TAM is located. A variety of human solid tumors and hematological malignancies have found that TAM is associated with poor prognosis. The ability of TAM to humor to tumor tissue makes molecular targeted therapy for TAM open up new ideas for tumor diagnosis and treatment and is an effective anti-tumor therapy.