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乙型肝炎病毒(HBV)感染患者,部分发生肝功能异常,甚至致死性肝衰竭。如果弄清慢性乙型肝炎病程中出现致死性肝衰竭的相关病因,就可设法采取预防措施,以降低慢性乙型肝炎的死亡率。最近报道,部分慢性乙型肝炎患者发生肝病活动或肝衰竭与重叠其他嗜肝病毒感染有关,也可见于HBeAg至抗-HBe的血清转换期。为此,我们探讨了142例慢性乙型肝炎病程中发生致死性肝衰竭时其他嗜肝病毒重叠感染和HBeAg和抗-HBe血清学状态的情况,试图找出部分相关病因。 1 材料和方法 1.1 材料中山医科大学第三附属医院传染病科1992-02/1998-11发生致死性肝衰竭的慢性乙型肝炎住院患者142例,男132例,女10例,平均年龄(48±13)岁,来自香港1例,广东
Hepatitis B virus (HBV) infection in patients with partial liver dysfunction, and even fatal liver failure. If you know the cause of fatal liver failure in the course of chronic hepatitis B, try to take preventive measures to reduce the mortality rate of chronic hepatitis B. Recently, some chronic hepatitis B patients with liver disease activity or liver failure and overlap with other Hepatitis virus infection, also seen in HBeAg to anti-HBe seroconversion. To this end, we explored the serological status of other Hepatitis viruses with overlapping infections and HBeAg and anti-HBe when fatal liver failure occurred in 142 patients with chronic hepatitis B and attempted to identify some of the related etiologies. 1 Materials and Methods 1.1 Materials Third Affiliated Hospital of Zhongshan Medical University Department of Infectious Diseases 1992-02 / 1998-11 fatal liver failure in hospitalized patients with chronic hepatitis B 142 cases, 132 males and 10 females, mean age (48 ± 13) years old, one from Hong Kong, Guangdong