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溶脲脲原体（Ｕｒｅａｐｌａｓｍ ａ Ｕｒｅａｌｙｔｉｃｕｍ ，Ｕ．Ｕ．）是泌尿生殖道感染的常见病原体，在Ｕ．Ｕ．上行性感染的动物模型中，大鼠睾丸出现明显的病理损伤。本文主要探讨Ｕ．Ｕ．感染（或作用）对小鼠Ｔ、Ｂ淋巴细胞功能的影响。体外实验，以对数生长期的Ｕ．Ｕ．、热灭活Ｕ．Ｕ．和Ｕ．Ｕ．上清（不含Ｕ．Ｕ．）感染（或作用）小鼠Ｔ淋巴细胞（脾细胞来源），采用ＭＴＴ法检测Ｔ淋巴细胞的增殖活性。体内实验，以上述Ｕ．Ｕ．感染（或作用）正常ＢＡＬＢ／ｃ小鼠，于ｄ５用ＳＲＢＣ免疫各小鼠，免疫后ｄ５测定各小鼠血清抗ＳＲＢＣ抗体凝集效价。结果表明：对数生长期的Ｕ．Ｕ．及热灭活Ｕ．Ｕ．和Ｕ．Ｕ．上清均能明显抑制小鼠Ｔ淋巴细胞的增殖和Ｂ淋巴细胞产生特异性抗体的能力，与对照组相比，有显著差异，Ｐ＜ ０．０１或０．０５。提示，Ｕ．Ｕ．感染可直接影响Ｔ淋巴细胞和Ｂ淋巴细胞的功能。
Ureaplasma Urealyticum (U. U.) is a common causative agent of genito-urinary tract infections at U. U. In the animal model of ascending infection, the rat testes showed obvious pathological damage. This article mainly discusses U. U. Effect of Infection (or Action) on the Function of T, B Lymphocytes in Mice. In vitro experiments to logarithmic growth phase U. U. , Heat inactivated U. U. And U. U. The supernatant (without U.U.) infected (or acted) mouse T lymphocytes (spleen cells), and the proliferation activity of T lymphocytes was detected by MTT assay. In vivo experiments, above U. U. The BALB / c mice were infected (or acted as normal), and each mouse was immunized with SRBC at d5. The anti-SRBC antibody agglutination titer of each mouse serum was determined after d5 immunization. The results show that the logarithmic growth phase of U. U. And heat inactivation U. U. And U. U. Supernatant can significantly inhibit the proliferation of mouse T lymphocytes and B lymphocytes produce specific antibodies, compared with the control group, there were significant differences, P <0.01 or 0.05. Prompt, U. U. Infection can directly affect the function of T lymphocytes and B lymphocytes.