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用放射配体结合法测定３６例多器官衰竭（ＭＯＦ）患者血白细胞糖皮质激素受体（ＧＣＲ）和血浆皮质醇（Ｆ）的变化，并行ＡＰＡＣＨＥⅡ评分。结果：①ＭＯＦ患者ＧＣＲ为１１９４８±１０８８．９位点／细胞，明显低于正常人４５２６．６±４５２．６位点／细胞（Ｐ＜０．０１）；其下为７６７．２８±４３０．５６ｎｍｏｌ／Ｌ，高于正常人３５３．２８±１１５．９２ｎｍｏｌ／Ｌ（Ｐ＜０．０５）。②ＭＯＦ患者衰竭器官数与ＧＣＲ、ＡＰＡＣＨＥⅡ关系密切，与Ｆ浓度无关。③ＭＯＦ患者ＧＣＲ下降与下浓度升高关系亦不大。作者认为合理使用外源性糖皮质激素或提高ＧＣＲ水平有益ＭＯＦ的防治。
The levels of glucocorticoid receptor (GCR) and plasma cortisol (F) in 36 patients with multiple organ failure (MOF) were measured by radioligand binding method and APACHEⅡ scores were evaluated. Results: ①The GCR of MOF patients was 11948 ± 1088.9 sites / cell, which was significantly lower than 4526.6 ± 452.6 sites / cells (P <0.01) in normal MOF patients and 767.28 ± 430.56 nmol / L, higher than the normal 353.28 ± 115.92nmol / L (P <0.05). ②MOF patients with organ failure and GCR, APACHE Ⅱ closely related to the concentration of F has nothing to do. ③ MOF decreased in patients with lower GCR concentration and the relationship is not large. The author believes that the rational use of exogenous glucocorticoid or increase the level of GCR beneficial MOF prevention and treatment.