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To assess the clinical effects ofenteral nutrition on intestinal structure and function in the early stage of severe bs. Methods: Nineteen cases of severe b injury were divided randomly into enteral nutrition group (EN) and parenteral nutrition group (PN). Gastrin, motilin, malondialdehyde (MDA), superoxide dismutase (SOD), endotoxin, rumor necrosis (TNF), diamine oxidase (DAO) and lactulose/mannitol (L/M) were determined on postb day 1, 4, 8, 14 (PBD) respectively. Results: Serum gastrin and motilin on PBD 4 and 8 were significantly higher in EN group than in PN group (P＜0.05-0.01). Plasma MDA on PBD4 and PBD8 was obviously lower in EN group than in PN group (P＜0.01). Plasma SOD on PBD4 and PBD8 was significantly higher in EN group than in PN group (P＜0.01). At the most time points, endotoxin and TNF were significantly lower in EN group than in PN group (P＜0.01). Serum DAO tended to decrease in EN group, and on PBD4 it was obviously lower in EN group than in PN group (P＜0.01). Gut permeability L/M on PBD4, PBD8 was obviously in EN group lower than in PN group (P＜0.05-0.01). There was positive correlation between L/M and DAO, and between MDA and TNF (P＜0.05-0.01), and negative correlation between L/M and SOD (P＜0.01). Conclusion: On the basis of the findings, it is considered that the early enteral nutrition is more effective to preserve the secretion and motility of gastrointestinal tract, decrease intestinal ischemia and reperfusion injury, reduce intestinal permeability, decrease plasma endotoxin and mediators,and maintain mucosa barrier function. Enteral nutrition is superior to parenteral nutrition in the early stage of severe bum injury.