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作者报告用小剂量鬼臼乙叉甙治疗11例骨髓增生异常综合征(MDS)病人的结果。病人和方法 11例中4例为难治性贫血伴原始细胞过多向白血病过度型(RAEB-T),7例 MDS 转化为急性白血病(AL)。用小剂量鬼臼乙叉甙治疗,剂量为50mg(24～37mg/M~2),静脉滴注2小时,每周治疗2～7次不等,根据原始细胞数量的多少及中性粒细胞减少的程度而定。如出现中性粒细胞严重减少,治疗暂停1～3周。疗程在4周以上。
The authors report the results of treating 11 patients with myelodysplastic syndrome (MDS) with a small dose of etoposide. Among the 11 patients, 4 were refractory anemia with excess leukemia over-expression (RAEB-T) and 7 were converted to acute leukemia (AL). With a small dose of etoposide treatment, a dose of 50mg (24 ~ 37mg / M ~ 2), intravenous infusion of 2 hours, 2 to 7 times a week treatment, according to the number of primary cells and neutrophils Depending on the degree of reduction. If there is a serious reduction in neutrophils, treatment is suspended for 1 to 3 weeks. Treatment in more than 4 weeks.