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目的研究除药物治疗外,透析方式的选择如血液透析及血液透析滤过对慢性肾衰竭(尿毒症期)患者贫血的影响。方法选择徐州医学院附属医院维持性血液透析患者60例,随机分为血液透析组(HD)及血液透析滤过组(HDF),60例患者均应用促红细胞生成素、叶酸及铁剂治疗贫血,分别记录治疗前和治疗12周后患者血红蛋白(Hb)、红细胞压积(HCT)及血清铁蛋白(Sf)、超敏C反应蛋白(hs-CRP)的变化。结果治疗12周后,血液透析滤过组(HDF)患者Hb、HCT、Sf改善程度优于血液透析组(HD),差异有统计学意义(P<0.05)。结论在相同改善贫血药物治疗下,血液透析滤过在改善慢性肾衰竭(尿毒症期)患者贫血方面作用优于血液透析。
Objective To investigate the effects of dialysis methods such as hemodialysis and hemodiafiltration on anemia in patients with chronic renal failure (uremia) in addition to drug treatment. Methods Sixty patients with maintenance hemodialysis in Affiliated Hospital of Xuzhou Medical College were randomly divided into hemodialysis group (HD) and hemodiafiltration group (HDF). All 60 patients were treated with erythropoietin, folic acid and iron for anemia The changes of hemoglobin (Hb), hematocrit (HCT), serum ferritin (Sf) and high sensitivity C-reactive protein (hs-CRP) were recorded before and 12 weeks after treatment. Results After 12 weeks of treatment, the improvement of Hb, HCT and Sf in hemodiafiltration group (HDF) was better than that in hemodialysis group (P <0.05). Conclusions Hemodialysis filtration is superior to hemodialysis in improving anemia in patients with chronic renal failure (uremia) under the same anemic drug treatment.