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目的:比较自制的超顺磁性氧化铁(superparamagnetic iron oxide,SPIO)和二乙烯五胺乙酸钆(Gd-DT-PA)用于磁共振诊断肝癌的效果。方法:大耳白兔24只,随机分为两组,每组12只,开腹直视接种法建立VX2肝癌模型。种植后7天、14天分别进行MR平扫及增强扫描并与病理组织学结合评价诊断正确率。结果:种植后7天12个病灶SPIO确诊10个(83.3%),Gd-DTPA13个病灶确诊为9个(69.2%),两组比较差异有统计学意义(P<0.05);种植后14天19个病灶SPIO确诊16个(84.2%),Gd-DTPA17个病灶确诊15个(88.2%),差异无统计学意义(P>0.05)。结论:合成的SPIO可作为MR造影剂诊断早期小病灶肝癌。
OBJECTIVE: To compare the effects of home-made superparamagnetic iron oxide (SPIO) and gadolinium tetraacetate (Gd-DT-PA) on the diagnosis of liver cancer by magnetic resonance. Methods: Twenty-four rabbits were randomly divided into two groups (n = 12 each). VX2 hepatocellular carcinoma model was established by direct inoculation. Seven days after planting, 14 days MR scan and enhanced scan and histopathology combined evaluation of diagnostic accuracy. RESULTS: Ten lesions (83.3%) were diagnosed in 12 lesions on day 7 after implantation and 9 lesions (69.2%) on 13 lesions of Gd-DTPA. The differences between the two groups were statistically significant (P <0.05) There were 16 confirmed cases (84.2%) in 19 lesions and 15 confirmed lesions (88.2%) in 17 lesions of Gd-DTPA, with no significant difference (P> 0.05). Conclusion: The synthesized SPIO can be used as MR contrast medium in the diagnosis of small early stage liver cancer.