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苯并芘(Ba P)作为多环芳烃类(PAHs)中毒性最大的一种强烈致癌物,广泛存在于生产和生活环境中,可诱发机体出现肿瘤,大量流行病学研究表明Ba P与肺癌、膀胱癌、皮肤癌和乳腺癌等多种癌症的发生密切相关。目前大量研究证实表观遗传学的改变与肿瘤发生密切相关。表观遗传学被定义为不依赖于DNA序列变化的基因活性的可遗传改变,表观遗传学机制主要包括:DNA甲基化异常、组蛋白修
As a kind of strong carcinogen with the highest toxicity among polycyclic aromatic hydrocarbons (PAHs), benzo [a] pyrene (BaP) widely exists in the production and living environment and can induce tumors in the body. A large number of epidemiological studies indicate that BaP is associated with lung cancer , Bladder cancer, skin cancer and breast cancer and other cancers are closely related. At present, a large number of studies confirm that epigenetic changes are closely related to tumorigenesis. Epigenetics is defined as a heritable change in gene activity independent of DNA sequence changes. Epigenetic mechanisms include: abnormal DNA methylation, histone modification