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目的:比较低分子肝素与雷米普利单用或联用治疗老年糖尿病肾病(DN)的临床疗效。方法:将120例老年DN患者按照奇偶数字法随机地均分为A、B、C三组,分别给予低分子肝素、雷米普利及二药联合治疗。比较三组临床疗效及治疗前后24h尿蛋白总量(UP)、血浆白蛋白(ALB)、血肌酐(Scr)、纤维蛋白原(FIB)水平变化情况。结果:A、B组临床总有效率(分别为70.00%、75.00%)显著低于C组(95.00%)(P<0.05);C组治疗后UP、FIB水平均显著低于A组、B组(P<0.05)。结论:低分子肝素与雷米普利联用治疗老年DN较二者单用疗效更为显著,应加以推广及应用。
Objective: To compare the clinical efficacy of low molecular weight heparin with ramipril alone or in combination for the treatment of senile diabetic nephropathy (DN). Methods: A total of 120 elderly DN patients were randomly divided into A, B and C groups according to the odd-even number method. Low molecular weight heparin, ramipril and two drugs were given respectively. The clinical curative effect and the level of urinary protein (ALB), serum albumin (ALB), serum creatinine (Scr) and fibrinogen (FIB) were compared between the three groups before and after treatment. Results: The total clinical effective rate (70.00%, 75.00%) in group A and group B was significantly lower than that in group C (95.00%) (P <0.05). The levels of UP and FIB in group C were significantly lower than those in group A and B Group (P <0.05). Conclusion: Low molecular weight heparin combined with ramipril in the treatment of elderly patients with DN more effective than the two alone is more significant, should be extended and applied.