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贝西沙星是一种治疗细菌性结膜炎的广谱抗菌剂。与其他喹诺酮类药物相比,其对易引发结膜炎的G+菌和G-菌、厌氧菌具有等效或较强的抗菌作用,对于某些对喹诺酮类药物产生耐药性的菌种,同样具有抗菌作用。同时,贝西沙星通过抑制眼部致炎因子的表达,进行免疫调节,从而更好地发挥其抗菌作用。贝西沙星滴眼后能迅速进入眼部各组织,且具有较长的药效时间。文中对贝西沙星的药理作用、药动学及临床试验进展进行综述。
Beixifloxacin is a broad-spectrum antibacterial agent for the treatment of bacterial conjunctivitis. Compared with other quinolones, it has an equivalent or strong antibacterial effect on G + and G- bacteria that cause conjunctivitis, and anaerobic bacteria. For some strains that are resistant to quinolones, The same antibacterial effect. At the same time, beixifloxacin can inhibit the expression of ocular inflammatory cytokines and immunomodulate, so as to better exert its antibacterial effect. Beixifloxacin drops rapidly into the eye tissues and has a longer duration of action. The pharmacological effects, pharmacokinetics and clinical trials of besixivin were reviewed in this paper.