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大剂量(≥1500μg/d)吸入皮质类固醇,由于全身性吸收可能导致下丘脑-垂体-肾上腺轴的抑制。因此,长期接受大剂量吸入类固醇治疗的哮喘患者可能在应激反应时发生肾上腺危象。患者和方法24例急性严重哮喘患者,入院前均无全身皮质类固醇治疗史。其中7例不吸入类固醇,17例定期吸入皮质类固醇。吸入量为4例600～1200μg/d,13例1500～2400μg/d。4例给予布地缩松(Bude-sonide),13例给予二丙酸氯地米松(Beclomethasonedipropionate)。体内可的松含量用放射免疫法测定。
Inhalation of corticosteroids at high doses (≥1500 μg / d) may result in inhibition of the hypothalamic-pituitary-adrenal axis due to systemic absorption. As a result, asthmatic patients who have been on long-term high-dose inhaled steroids may have adrenal crisis during stress response. Patients and Methods Twenty-four patients with acute severe asthma had no history of systemic corticosteroid therapy prior to admission. Of these, 7 did not inhaled steroids and 17 received regular corticosteroids. Inhalation of 4 cases of 600 ~ 1200μg / d, 13 cases of 1500 ~ 2400μg / d. 4 cases were given Bude-sonide and 13 cases were given Beclomethasoniedipropionate. Cortisone content was measured by radioimmunoassay.