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目的观察甲强龙冲击治疗对系统性红斑狼疮患者骨密度影响。方法回顾性分析该院2013年2月—2015年6月收治的系统性红斑狼疮患者120例病历资料,A组60例给予甲强龙冲击治疗,B组60例给予足量甲强龙治疗,同时选取正常对照60例作为C组。每半年对上述3组骨密度监测1次,连续观测18个月。结果研究0、6、12、18个月时,3组腰椎L1~L4、股骨颈骨骨密度水平差异无统计学意义(P>0.05)。经18个月的跟踪监测A组、B组腰椎L1~L4、股骨颈骨骨密度水平均显著低于C组,经比较差异有统计学意义(P<0.05)。结论系统性红斑狼疮患者长期接受甲强龙治疗,骨量流失,骨密度减少,增加了出现骨折的危险性,临床治疗过程中应加以关注并及早给予相应的防治措施。
Objective To observe the impact of methylprednisolone on bone mineral density in patients with systemic lupus erythematosus. Methods The clinical data of 120 patients with systemic lupus erythematosus (SLE) treated in our hospital from February 2013 to June 2015 were retrospectively analyzed. Group A (60 cases) was treated with methylprednisolone, while group B (60 cases) At the same time select 60 cases of normal control as C group. The bone mineral density of the above three groups was monitored once every six months for 18 months. Results At 0, 6, 12 and 18 months, there was no significant difference in BMD of L1 ~ L4 and femoral neck between the three groups (P> 0.05). After 18 months of follow-up monitoring, the BMD of L1 ~ L4 and femoral neck in group A and group B were significantly lower than those in group C (P <0.05). Conclusion Long-term treatment of patients with systemic lupus erythematosus with methylprednisolone treatment, bone loss, reduced bone mineral density, increased the risk of fractures, clinical treatment should be paid attention to and early to give appropriate control measures.