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本文对19例卵巢不同类型的上皮性肿瘤进行了雌激素受体(ER)及孕激素受体(PR)的免疫定位研究。ER、PR的分布方式有三种:腔膜型、弥散型及核主型。浆液性癌以腔膜型分布为主,宫内膜样癌多呈弥散型及核主型分布;2例分泌型宫内膜样癌(透明细胞癌)的孕激素受体均呈核主型分布,且呈明显强阳性。ER、PR的定位研究较生化法更直接地反映了雌、孕激素与卵巢肿瘤的关系,对临床内分泌治疗具有重要指导意义。
In this paper, immunophenotypes of estrogen receptor (ER) and progesterone receptor (PR) were studied in 19 patients with different types of epithelial ovarian tumors. ER, PR distribution in three ways: cavity membrane, diffuse and nuclear-based. Serous carcinoma was mainly distributed by luminal membrane, and endometrial carcinoma was mostly diffuse and nuclear-type distribution. The progesterone receptors of 2 secretory endometrioid carcinoma (clear cell carcinoma) Distribution, and was obviously strong positive. The localization of ER and PR reflects the relationship between estrogen and progesterone and ovarian tumors more directly than biochemical methods, which is of great guiding significance for clinical endocrine therapy.