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为探讨山东地区各型病毒性肝炎中庚型肝炎病毒（ＨＧＶ）的感染状况，采用逆转录－套式聚合酶链反应法（ＲＴ－ｎＰＣＲ）检测１５９例病毒性肝炎血清ＨＧＶ－ＲＮＡ。结果表明：甲型和戊型肝炎ＨＧＶ－ＲＮＡ均阴性。乙型肝炎ＨＧＶ－ＲＮＡ的检出率，在急性肝炎（０／２０）、慢性肝炎（２／５０）、肝硬变（１／１０）和慢性重型肝炎（１／５）依次升高。慢性丙型肝炎ＨＧＶ－ＲＮＡ的检出率为３０．０％。非甲－戊（ＮＡ－Ｅ）型肝炎ＨＧＶ－ＲＮＡ的检出率为２３．３％，且在急性肝炎（２／１５）、慢性肝炎（２／８）、肝硬变（３／５）中依次升高。肝细胞癌４例，２例ＨＧＶ－ＲＮＡ阳性。本组ＨＧＶ－ＲＮＡ阳性１９例中，８例有输血史，７例有多次住院史，４例感染来源不清。提示ＨＧＶ感染常见于乙、丙、非甲－戊型肝炎和肝癌中，其感染途径可能与输血和医院内传播有关。
In order to investigate the status of hepatitis G virus (HGV) infection in various types of viral hepatitis in Shandong Province, serum HGV-RNA was detected in 159 patients with viral hepatitis by reverse transcription-nested polymerase chain reaction (RT-nPCR). The results showed that both HGV-RNA of A and E were negative. The detection rate of hepatitis B virus HGV-RNA increased successively in acute hepatitis (0/20), chronic hepatitis (2/50), cirrhosis (1/10) and chronic severe hepatitis (1/5). The detection rate of chronic hepatitis C HGV-RNA was 30.0%. The detection rate of HGV-RNA in non-A-NA hepatitis was 23.3%, and in acute hepatitis (2/15), chronic hepatitis (2/8), cirrhosis (3/5) In turn increased. Hepatocellular carcinoma in 4 cases, 2 cases of HGV-RNA positive. Among the 19 patients with positive HGV-RNA in this group, 8 had transfusion history, 7 had multiple hospitalizations, and 4 had unclear sources of infection. It is suggested that HGV infection is common in hepatitis B, C, non-A-hepatitis E and hepatocellular carcinoma, and its infection may be related to blood transfusion and hospital transmission.