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自巴布亚新几内亚和印度尼西亚先后出现抗氯喹的间日疟原虫以来,根据Myint-Oo等(1992)的报告,在缅甸可能从1989年就有了抗氯喹的间日疟原虫。因此,作者报告两例尽管血清内氯喹浓度已达正常治疗水平,但对原虫血症仍无反应的间日疟病例。 病例1为一33岁初级工程师,从1991年5月至1992年6月一直在缅甸。1个月前因周期性发热、寒战、强直和出汗等曾服用1个疗程总剂量达1500mg的氯喹。连续的血涂片均查到间日疟原虫的滋养体和裂殖体。
Since chloroquine-resistant Plasmodium vivax has emerged in Papua New Guinea and Indonesia, according to the report of Myint-Oo et al. (1992), chloroquine-resistant P. vivax may have been available in Myanmar from 1989. Therefore, the authors report two cases of vivax malaria that still do not respond to parasitemia, despite the fact that the concentration of chloroquine in serum has reached the normal level of treatment. Case 1 was a 33-year-old junior engineer who had been in Myanmar from May 1991 to June 1992. 1 month ago due to periodic fever, chills, ankylosis and sweating had taken a course of treatment of a total dose of 1500mg of chloroquine. Continuous blood smears were found trophozoites and schizonts of Plasmodium vivax.