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探讨姜黄素对痤疮丙酸杆菌(propionibacterium acnes,P.acnes)/LPS诱导的小鼠爆发性肝炎的影响。实验分为正常组,对照组和姜黄素组。分别给予赋形剂或姜黄素治疗,7d后处死小鼠,评价治疗效果及检测相关免疫学指标。结果显示,和对照组相比,姜黄素给药显著提高小鼠生存率,降低血清谷丙转氨酶水平;降低肝脏CD4+T细胞数量和BrdU表达,降低巨噬细胞MHCⅡ、CD80和CD86表达。结果表明,姜黄素能缓解P.acnes/LPS诱导的爆发性肝炎,其机制可能与抑制CD4+T细胞浸润、增殖及巨噬细胞活化有关。
To investigate the effect of curcumin on propionibacterium acnes (P.acnes) / LPS-induced mouse fulminant hepatitis. The experiment was divided into normal group, control group and curcumin group. The animals were given excipients or curcumin treatment, 7d after the mice were sacrificed to evaluate the therapeutic effect and detection of relevant immunological indicators. The results showed that compared with the control group, curcumin administration significantly increased the survival rate of mice and decreased the level of alanine aminotransferase; decreased the number of CD4 + T cells and BrdU in liver and decreased the expression of MHCⅡ, CD80 and CD86 in macrophages. The results showed that curcumin can alleviate P.acnes / LPS-induced fulminant hepatitis, and its mechanism may be related to the inhibition of CD4 + T cell infiltration, proliferation and macrophage activation.