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随着临床免疫学检测技术的进展,以及对系统性红斑狼疮发病机制逐步深入的认识,目前对此病的诊断已不困难。然而许多免疫学诊断方法尚不能反映狼疮所导致的肾损害,因其损害程度不一定与全身疾病活动情况相平行。在少数病例中,狼疮性肾炎(LN)可以是该病的起病症状,此时难与原发性肾小球疾病鉴别;狼疮还可以损害全身各种脏器,而肾脏累及与否又对本病的预后起重要作用。一般临床检查,包括尿常规、肾功能等,仅能判断肾脏的功能,而难以了解病变的性质、受累的范围等。因此,临床上对狼疮病人,特别是已有肾脏损害者进行肾穿刺病理检查尤为重要,其意义在于:
With the progress of clinical immunological detection techniques and the understanding of the pathogenesis of systemic lupus erythematosus, the diagnosis of this disease is not difficult at present. However, many immunological diagnostic methods are not yet able to reflect the renal damage caused by lupus, because the degree of damage is not necessarily parallel with the systemic disease activity. In a few cases, lupus nephritis (LN) can be the onset of the disease symptoms, this time difficult to identify with primary glomerular disease; lupus can also damage the body of various organs, and kidney involvement or not The prognosis of this disease plays an important role. General clinical examination, including urine, kidney function, etc., can only determine the function of the kidney, and difficult to understand the nature of the lesion, the scope of involvement. Therefore, clinical lupus patients, especially those who have renal damage pathological examination of renal biopsy is particularly important, its significance is that: