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目的分析初诊T2DM男性患者并发骨质疏松后BMD的改变及相关因素,为早期诊断、早期防治T2DM男性患者并发骨质疏松提供理论依据。方法选取本院2009年至2012年入院初诊2型糖尿病男性患者36例。通过定量QCT测定第3腰椎总骨矿含量和骨密度,依骨密度将其分为有骨质疏松组和无骨质疏松组。再取同期来院进行常规体检,肝肾功能、血糖正常,无其他基础疾病的正常男36例。分别测定骨密度及各生化指标并比较。结果糖尿病组较对照组骨质疏松发病率高,差异有统计学意义,P<0.05。骨质疏松组较无骨质疏松组尿Ca/Cr高、血T低,体重指数低,差异有统计学意义,P<0.05。血钙、磷、BGP、PTH,尿CTX/Cr,ALP的差异无统计学意义,P>0.05。结论 2型糖尿病的患者较易并发骨质疏松,其发生和高尿Ca/Cr、低血T和低体重指数有关。
Objective To analyze the changes and related factors of BMD in newly diagnosed T2DM male patients with osteoporosis and provide theoretical basis for early diagnosis and early prevention and treatment of T2DM in male patients with osteoporosis. Methods Totally 36 male patients with type 2 diabetes admitted to our hospital from 2009 to 2012 were selected. Quantitative QCT was used to determine the total bone mineral density and bone mineral density of the third lumbar vertebra. According to the bone mineral density, the bone mineral density was divided into osteoporosis group and osteoporosis group. Then take the same period to hospital for routine physical examination, liver and kidney function, normal blood sugar, no other basic diseases in 36 cases of normal males. Bone mineral density and biochemical parameters were measured and compared. Results The incidence of osteoporosis in diabetic group was significantly higher than that in control group (P <0.05). Compared with no osteoporosis group, osteoporosis group had higher urinary Ca / Cr, lower blood T and lower body mass index, with a significant difference (P <0.05). There was no significant difference in serum calcium, phosphorus, BGP, PTH, urinary CTX / Cr and ALP, P> 0.05. Conclusions Patients with type 2 diabetes tend to be complicated by osteoporosis. The occurrence of osteoporosis is related to high urinary Ca / Cr, low blood T and low body mass index.