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1713年就有关于棉尘症的记载,1877年Proust首先使用棉尘症(Byssinosis)这一术语,其病因和发病机制至今却仍是个谜。通过大量研究,目前一般认为是棉苞片、叶、茎等植物碎片的水溶性萃取物中的某些生物活性物质,而不是棉纤维本身致病。对于棉尘症的发病机制,曾提出过组织胺释放、革兰氏阴性菌及其内毒素、抗原-抗体反应等假说。虽上述假说能部分地解释棉尘症的急性症状,但还不能圆满地解释棉尘症发生发展过程,特别是由急性向慢性“不可逆”作用发展的演变过程。近年来,随着人们对巨噬细胞(以下简称MΦ)和嗜中性粒细胞以及它们所分泌的生物活性物质的研究逐步深入,对这些
In 1713, there was a description of cotton dust disease. The etiology and pathogenesis of Proust first used the term Byssinosis in 1877 remains a mystery. Through a large number of studies, it is generally considered that some bioactive substances in the water-soluble extracts of plant fragments such as cotton bract, leaves, stems, etc., rather than the cotton fiber itself. For the pathogenesis of cotton dust disease, there have been proposed histamine release, Gram-negative bacteria and its endotoxin, antigen-antibody reaction hypothesis. Although these hypotheses can partly explain the acute symptoms of cotton dust disease, they can not satisfactorily explain the occurrence and development of cotton dust disease, especially the evolution from acute to chronic “irreversible” effects. In recent years, with the further research on macrophages (hereinafter referred to as MΦ) and neutrophils and their bioactive substances secreted, these