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目的探讨强直性脊柱炎(AS)患者血清中白细胞介素27(IL-27)的表达水平及其临床意义。方法抽取2014年3月-2016年11月本院收治的AS患者76例,根据Bath强直性脊柱炎病情活动指数(BASDAI)将入选患者分为稳定组(BASDAI≤4)与活动组(BASDAI>4),每组38例;另取同期健康体检者38例为对照组。3组患者均于入院后抽取空腹静脉血检测血清中IL-27、C反应蛋白(CRP)及红细胞沉降率(ESR)含量,对比3组血清中IL-27、CRP及ESR水平,分析AS患者血清IL-27水平与CRP、ESR及BASDAI的相关性。结果对照组血清IL-27、ESR、CRP水平均低于稳定组与活动组,同时活动组血清IL-27、ESR、CRP水平及BASDAI均高于稳定组,差异有统计学意义(均P<0.05);AS患者血清IL-27水平与ESR、CRP及BASDAI明显呈正相关(P<0.05)。结论AS患者血清IL-27水平随病情活动度增高而升高,IL-27水平与ESR、CRP及BASDAI呈正相关,可作为评价病情发展的一个重要指标。
Objective To investigate the expression of interleukin 27 (IL-27) in patients with ankylosing spondylitis (AS) and its clinical significance. Methods Seventy-six AS patients admitted to our hospital from March 2014 to November 2016 were enrolled in this study. According to the Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), the patients were divided into three groups: BASDAI≤4 and BASDAI> 4), each group of 38 cases; another take the same period, 38 healthy subjects as the control group. Serum levels of IL-27, C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) were measured in all three groups after admission. The levels of IL-27, CRP and ESR were compared between the three groups. Correlation of serum IL-27 level with CRP, ESR and BASDAI. Results Serum levels of IL-27, ESR and CRP in control group were lower than those in stable group and active group. Serum levels of IL-27, ESR, CRP and BASDAI in active group were significantly higher than those in stable group (all P < 0.05). Serum IL-27 level in patients with AS was positively correlated with ESR, CRP and BASDAI (P <0.05). Conclusions The level of IL-27 in patients with AS increases with the increase of disease activity. The level of IL-27 is positively correlated with ESR, CRP and BASDAI, which may be used as an important index to evaluate the disease progression.