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血栓性血小板减少性紫癜(TTP)是一种异质性疾病,具有血小板减少性紫癜、微血管病性溶血性贫血、肾功能异常、一系列变化不定的神经学异常及发热等五个特征。其特有的实验室所见为:贫血伴红细胞寿命缩短、红细胞碎片、周围血片中出现有核红细胞、血小板减少伴血小板寿命缩短及纤维蛋白降解产物增加伴相对正常的纤维蛋白原转换率,提示由于进行性微血管血栓形成和继发性纤溶所致。血小板在微血栓中的突出作用和明显的消耗性血小板减少,使抗血小板疗法被用于TTP的急性处理。尽管TTP的共同病因在许多临床病例中还不清楚,但在没有DIC的情况下,血小板聚集物是构成动脉和毛细血管玻璃样阻塞物的主要成分,此与病因可能有关。其可能的
Thrombotic thrombocytopenic purpura (TTP) is a heterogeneous disease with five characteristics of thrombocytopenic purpura, microangiopathic hemolytic anemia, abnormal renal function, a series of variable neurological abnormalities and fever. Its unique laboratory findings are: anemia with shortened life span of red blood cells, red blood cell debris, peripheral blood cells appear in the nucleated red blood cells, thrombocytopenia with shortened platelet life expectancy and increased fibrin degradation products with a relatively normal fibrinogen conversion rate, suggesting Due to progressive microvascular thrombosis and secondary fibrinolysis. The prominent role of platelets in microthrombi and significant depleting thrombocytopenia has led to antiplatelet therapy for the acute management of TTP. Although the common cause of TTP is unclear in many clinical cases, platelet aggregation is a major component of arterial and capillary glass-like obstructions in the absence of DIC, which may be related to the etiology. It is possible