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慢性肝炎的预后和治疗部分取决于其组织学活性及肝纤维化的程度。本文研究慢性肝炎患者血清Ⅲ型前胶原N端多肽(PⅢNP)作为组织学活性标记及血清Ⅰ型胶原(CI)作为纤维化标记的意义。 60例患者依组织学表现分为慢迁肝、慢活肝、非活动性肝硬化及活动性肝硬化四组。组织学活性按0～21分评分:门脉周围和架桥坏死0～10,门脉炎症0～4,小叶炎症0～3,小叶坏死0～4。按评分将纤维化分为0～5级:0级:无纤维化;1级:门脉和门脉周围纤维化;2级:门脉及其周围纤维化伴静脉周围纤维化;3级:不完全性肝硬化;4级:有细纤维隔的肝硬化;5级:有大纤维隔或广泛窦周纤维化的肝硬化。血清PⅢNP和CI运用液相RIA法测定。
The prognosis and treatment of chronic hepatitis depends in part on its histological activity and the degree of liver fibrosis. This study was to investigate the significance of serum type Ⅲ procollagen N-terminal polypeptide (PⅢNP) in patients with chronic hepatitis as a marker of histological activity and serum type I collagen (CI) as markers of fibrosis. Sixty patients were divided into four groups according to histological findings: slow-moving liver, slow-living liver, non-active cirrhosis and active cirrhosis. Histological activity score of 0 ~ 21: around the portal vein and bridge necrosis 0 ~ 10, portal inflammation 0 ~ 4, lobular inflammation 0 ~ 3, 0 ~ 4 lobular necrosis. According to the score will be divided into fibrosis 0 to 5: 0: no fibrosis; 1: portal and portal vein fibrosis; 2: portal vein and its surrounding fibrosis with peripheral fibrosis; 3: Incomplete liver cirrhosis; Grade 4: fibrotic septum cirrhosis; Grade 5: cirrhosis with large fibroids or extensive sinus fibrosis. Serum PⅢNP and CI using liquid phase RIA method.