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目的 观察口服氨酰心安和依那普利治疗血管迷走性晕厥的疗效。方法 对 48例直立倾斜试验 (head uptilttesting ,HUT)阳性的晕厥患者随机分三组治疗 :A组口服氨酰心安 ;B组口服依那普利 ;C组不给药物治疗 ,30天后复查HUT ,中短期随访晕厥复发率。结果 服药后HUT转阴率 :A组为 75 % ,B组为 5 6 3% ,C组为 18 8%。经 χ2 检验 ,A组与C组比较P <0 0 1,差异有显著性 ,而A组与B组和B组与C组比较P >0 0 5 ,差异无显著性。随访 1～ 14(7 4± 3 9)个月 ,三组晕厥复发率差异无显著性 ,A组耐受性好。结论 口服氨酰心安治疗血管迷走性晕厥 ,重复HUT转阴率高于依那普利 ,推测该药是防治血管迷走性晕厥的有效方法。但中短期治疗随访观察未见对晕厥复发率产生影响。
Objective To observe the efficacy of oral atenolol and enalapril in the treatment of vasovagal syncope. Methods Forty-eight patients with positive syncope of head uptilting (HUT) were randomly divided into three groups: A group received oral atenolol; B group enalapril; C group received no drug treatment; HUT was examined after 30 days, Short-term follow-up of syncope recurrence rate. Results After treatment, the rate of HUT negative conversion was 75% in group A, 56.3% in group B and 18.8% in group C, respectively. The χ2 test showed that there was significant difference between group A and group C (P <0.01), but there was no significant difference between group A and group B and group B and group C (P> 0.05). The follow-up ranged from 1 to 14 (74 ± 39) months. There was no significant difference in the relapse rate of syncope between the three groups, and the group A was well tolerated. Conclusion oral administration of atenolol treatment of vasovagal syncope, repeat HUT negative rate higher than enalapril, presumably the drug is an effective method of prevention and treatment of vasovagal syncope. However, short-term follow-up treatment did not observe the recurrence rate of syncope affected.