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目的:研究血清淀粉样蛋白(SA)A1基因多态性与重度肥胖儿童血脂的关系。方法:选择65名重度肥胖儿童作为研究对象,同时选取65名同性别、同年龄的正常体重儿童作为对照组,分别测量他们的身高、体重,计算体重指数,检测血脂(TC、LDL-C、TG)和SAA浓度并进行对比,同时检测四种单核苷酸多态性(SNPs)的基因型,比较两组儿童四种SNPs的分布频率及各基因型间SAA的浓度。结果:重度肥胖儿童SAA血浆浓度和TC、LDL-C、TG一样明显高于正常对照组,rs12218和rs4638289两种SNPs分别频率在重度肥胖儿童中较正常组高,而其它两组SNPs则在两组儿童中无明显差异,但只有rs4638289基因多态性显示与SAA浓度有关。结论:SAA1基因多态性与重度肥胖儿童血脂密切相关。
Objective: To investigate the relationship between the polymorphism of serum amyloid protein (A1) gene and the blood lipids in severe obese children. Methods: Sixty-five children with severe obesity were enrolled in this study. Sixty-five healthy children of the same sex and age were enrolled in this study. Their height, weight, body mass index (BMI), body mass index TG and SAA were detected and compared. At the same time, the genotypes of four single nucleotide polymorphisms (SNPs) were detected. The distribution frequency of four SNPs and the concentration of SAA between different genotypes were compared. Results: The plasma concentrations of SAA in severe obese children were significantly higher than those in normal controls, as well as TC, LDL-C and TG. The frequencies of rs12218 and rs4638289 in children with severe obesity were significantly higher than those in normal children, while the other two SNPs were in two There was no significant difference between groups of children, but only rs4638289 gene polymorphism was associated with SAA concentration. Conclusion: SAA1 gene polymorphism is closely related to the lipid profile of obese children.