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目的探讨抗铁蛋白轻链(ferritin light chain,FTL)自身抗体(以下简称FTL抗体)在常见消化道肿瘤诊断中的价值。方法用ELISA法检测消化道癌症患者(食管癌、胃癌、原发性肝癌均为250例),慢性肝病患者(乙肝120例、丙肝54例、肝硬化58例)和113例正常人血清中的FTL抗体,比较不同组间FTL抗体含量及阳性率的差异。结果各癌症组FTL抗体含量均高于正常对照组(均P<0.001),其中肝癌组FTL抗体含量高于食管癌组和胃癌组(均P<0.001);肝癌组FTL抗体含量高于慢性肝病组(P=0.000),慢性肝病组FTL抗体含量高于正常对照组(P=0.000);食管癌、胃癌、肝癌、慢性肝病组FTL抗体阳性率分别为46.8%、48.4%、61.6%、32.3%,均高于正常对照组的0.9%(均P=0.000),其中肝癌组抗体阳性率高于食管癌、胃癌和慢性肝病组(均P<0.01),慢性肝病组抗体阳性率高于正常对照组(χ2=43.738,P=0.000);FTL抗体检测食管癌、胃癌、肝癌的灵敏度分别为46.8%、48.4%、61.6%,特异度均为99.1%。结论 FTL抗体在消化道肿瘤患者体内含量增高,对于诊断消化道肿瘤有一定意义。
Objective To investigate the value of anti-ferritin light chain (FTL) autoantibodies (hereinafter referred to as FTL antibodies) in the diagnosis of common gastrointestinal tumors. Methods Serum samples from patients with gastrointestinal cancer (esophageal cancer, gastric cancer and primary liver cancer were all detected by ELISA) were detected by ELISA in 120 cases of chronic liver disease (120 cases of hepatitis B, 54 cases of hepatitis C, 58 cases of cirrhosis and 113 cases of normal) FTL antibody to compare the different groups of FTL antibody content and positive rate differences. Results The levels of FTL antibody in all cancer groups were higher than those in normal control group (all P <0.001). The levels of FTL antibody in liver cancer group were higher than those in esophageal cancer group and gastric cancer group (all P <0.001) (P = 0.000). The positive rate of FTL antibody in chronic liver disease group was 46.8%, 48.4%, 61.6%, 32.3% respectively, and the positive rate of FTL antibody in chronic liver disease group was higher than that in normal control group (P = 0.000) %, Respectively, which were higher than those in normal control group (all P = 0.000). The positive rate of antibody in HCC group was higher than that in esophageal cancer, gastric cancer and chronic liver disease group (all P <0.01) (Χ2 = 43.738, P = 0.000). The sensitivity of FTL antibody detection for esophageal cancer, gastric cancer and liver cancer were 46.8%, 48.4% and 61.6% respectively, and the specificity was 99.1%. Conclusion FTL antibody levels in patients with gastrointestinal tumors increased, for the diagnosis of gastrointestinal cancer has some significance.