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目的通过醋酸甲孕酮和化疗合用的方法,探讨晚期大肠癌患者化疗中改善生活质量的有效措施。方法98例大肠癌患者随机分成两组。治疗组化疗期间采用甲孕酮500mg,每日2次口服,8周为一观察周期。对照组采用单独化疗。结果治疗组与单独化疗组相比,疼痛缓解率(30.5%),食欲增加(38.7%),体重增加(46.9%),骨髓保护较理想,取得了满意的疗效。结论250mg甲孕酮能有效改善大肠癌患者化疗期间的食欲,增加体重,缓解疼痛。
Objective To explore effective measures for improving quality of life in patients with advanced colorectal cancer through the combination of medroxyprogesterone acetate and chemotherapy. Methods 98 patients with colorectal cancer were randomly divided into two groups. The treatment group was treated with medroxyprogesterone 500 mg during the chemotherapy period, 2 times a day orally, and 8 weeks as an observation period. The control group used chemotherapy alone. Results Compared with the chemotherapy alone group, the treatment group had a pain relief rate (30.5%), increased appetite (38.7%), weight gain (46.9%), and better bone marrow protection, achieving satisfactory results. Conclusion 250 mg medroxyprogesterone can effectively improve the appetite, increase body weight, and relieve pain in patients with colorectal cancer during chemotherapy.