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目的探讨分娩镇痛对产妇雌孕激素水平的影响。方法据产妇意愿将自然分娩的初产妇262例分为观察组148例和对照组114例,观察组给予微量罗哌卡因联合芬太尼硬膜外麻醉分娩镇痛,对照组常规分娩法处理,2组产妇均在第三产程末和产后5d抽肘静脉血进行雌二醇(E2)、孕酮(P)检测。结果 2组孕产妇第三产程末和产后5d的E2、P水平差异均无统计学意义(P>0.05);但2组中产后抑郁者的产后5d的E2及P均低于正常产妇,差异均有统计学意义(P<0.05)。结论分娩镇痛对产妇雌孕激素水平改变无显著性差异的影响,是一种安全可靠的镇痛方法,在临床工作中应大力提倡硬膜外麻醉分娩镇痛。
Objective To investigate the effect of labor analgesia on estrogen and progesterone in pregnant women. Methods 262 cases of primipara caused by spontaneous labor were divided into observation group (148 cases) and control group (114 cases). The observation group was given epidural analgesia with ropivacaine combined with fentanyl, and the control group was given conventional delivery . In both groups, the estradiol (E2) and progesterone (P) levels were measured in the elbow venous blood at the end of the third stage of labor and 5 days after delivery. Results There was no significant difference in E2 and P levels between the end of the third stage of labor and the 5th day of postpartum in the two groups (P> 0.05). However, the E2 and P of postpartum depression in both groups were lower than that of normal males All were statistically significant (P <0.05). Conclusions Labor analgesia has no significant difference on estrogen and progesterone levels. It is a safe and reliable analgesic method. Epidural anesthesia labor analgesia should be advocated in clinical practice.