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为探讨肿瘤坏死因子－α在伴有血管病变的Ⅱ型糖尿病患者胰岛素抵抗发生中的意义，采用放射免疫法检测了４０例Ⅱ型糖尿病患者血清肿瘤坏死因子－α水平，比较其在伴有或无血管并发症的Ⅱ型糖尿病患者中的差别并分析其与胰岛素敏感性的关系。结果显示，伴有血管并发症的Ⅱ型糖尿病患者血清肿瘤坏死因子－α含量明显高于无血管并发症的Ⅱ型糖尿病患者，且与胰岛素敏感性呈负相关。提示肿瘤坏死因子－α在胰岛素抵抗发生中起重要作用。
To investigate the significance of tumor necrosis factor-α in the development of insulin resistance in type 2 diabetes mellitus patients with vascular lesions, the levels of serum tumor necrosis factor-α in 40 type Ⅱ diabetic patients were detected by radioimmunoassay Differences in type 2 diabetes mellitus without vascular complications and analysis of their association with insulin sensitivity. The results showed that serum T2DM patients with type 2 diabetes mellitus complicated with vascular complications were significantly higher than those with type II diabetes mellitus without complications and negatively correlated with insulin sensitivity. Tumor necrosis factor-α is suggested to play an important role in the development of insulin resistance.