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早产儿动脉导管未闭(PDA)导致血液左向右分流,若分流量比较大,将使由於肺表面活性物质不足而已受损伤的肺功能更进一步地恶化,亦可影响其他肺部疾患的临床过程,如Wilson-Mikity综合征、新生儿肺炎或频繁发作的呼吸暂停和心动过缓等。因此,对於PDA伴有呼吸窘迫综合征或其他肺部疾患早产儿的处理,在过去几年中一直成为热烈争论的问题,其中特别是应用前列腺素合成抑制剂的药理作用来关闭动脉导管,并且在严重PDA患儿中作为取代手术结扎的可能措施,已陆续有过报道。本文就此问题作进一步介绍。
Premature infants with patent ductus arteriosus (PDA) cause left-to-right shunting of the blood. If the shunting volume is relatively large, lung function, which has been impaired due to insufficient pulmonary surfactant, may be further aggravated, and clinical effects of other lung diseases may also be affected Processes such as Wilson-Mikity syndrome, neonatal pneumonia or frequent episodes of apnea and bradycardia. Therefore, the management of PDA with premature infants with respiratory distress syndrome or other pulmonary disorders has been a subject of great controversy over the past few years, in which, inter alia, the pharmacological effects of prostaglandin synthesis inhibitors are used to close the ductus arteriosus, And in severe cases of PDA as a possible replacement for surgical ligation may have been reported. This article on this issue for further introduction.