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抑癌基因是一类生长控制基因或负调控基因,正常情况下可抑制转化细胞的恶性表型,当它们发生缺失或突变而丧失功能时,将会导致细胞的恶性转化。PTEN基因是迄今为止发现的第1个具有双特异性磷酸酶活性的抑癌基因,参与了细胞正常生长发育过程的多个环节。该基因的突变失活与多种肿
Tumor suppressor gene is a kind of growth control gene or negative regulation gene, which can inhibit the malignant phenotype of transformed cells under normal circumstances. When they have loss or mutation, they will lead to malignant transformation of cells. PTEN gene is the first tumor suppressor gene with bispecific phosphatase activity discovered so far, which is involved in many aspects of normal cell growth and development. The gene mutation inactivation and a variety of swollen