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尽管在80年代早期艾滋病开始流行以来,与HIV-相关的皮肤病在临床和实验室进行了反复的科学性研究,但是皮肤免疫调节机制对免疫系统缺陷时的作用形式仍然不清楚。在紫外线(UV)-照射治疗的过程中UV-照射对皮肤的免疫系统有着重要的作用,并且有效地运用于对蕈样肉芽肿、异位性皮炎、银屑病和一些其他的皮肤病的治疗。然而让人担忧的是紫外线光的免疫抑制作用可能对HIV-阳性病人的主要疾病的负面影响,以致于光治疗作为最后的治疗措施。一些体外的研究和转基因鼠的实验均证实紫外线B(UVB)和PUVA能够诱导病毒在人体内复制。然而迄今为止在人体临床研究中没有证实在UV-治疗下能减短HIV-病人的生存时间。
Although HIV-related dermatology has been repeatedly scientifically studied in clinical and laboratory settings since the onset of AIDS in the early 1980s, the role of skin immunomodulatory mechanisms in immune system deficits remains unclear. UV-irradiation plays an important role in the immune system of the skin during UV-irradiation therapy and is effective for the treatment of mycosis fungoides, atopic dermatitis, psoriasis and some other dermatological conditions treatment. However, there is concern that the immunosuppressive effects of ultraviolet light may have a negative impact on the major diseases of HIV-positive patients so that light therapy is the last resort. Some in vitro studies and experiments in transgenic mice confirm that UVB and PUVA induce the virus to replicate in humans. However, in human clinical studies to date, however, it has not been demonstrated that UV-therapy can shorten the life span of HIV-patients.