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目的 为探讨胎儿期铅暴露对婴儿时期体格生长的影响,以脐血铅水平作为反映胎儿期铅暴露的示标,前瞻性观察了生后12月内婴儿的体格生长状况.方法 收集有效脐血标本348份进行血铅测定,发现有40%者出生时脐血铅水平超过目前国际上公认是有害的水平(100μg/L).根据脐血铅水平将婴儿分为高铅组和低铅组,在生后3月、6月和12月龄时对其体重、身长和头围进行纵向随访.结果 我们在单因素分析中发现,高低铅组婴儿在3、6和12月龄时体重、身长和头围的离均差值均较接近,仅3月龄时体重的差别有统计学意义.用协方差分析的方法的分别校正这些影响因素后,再比较高低铅组间的差别,发现3月龄时高铅组儿童的体重仍显著落后于低铅儿童.结论 胎儿期铅暴露可能对婴儿早期的体格生长有不良影响.但这种作用在短期内为生后的其他影响因素所掩盖而显得不甚明显.
Objective To investigate the impact of fetal lead exposure on physical growth during infancy and to use cord blood lead as a marker of fetal lead exposure in a prospective manner to observe the growth status of infants during the first 12 months of life.Methods To collect effective cord blood 348 samples of blood lead determination, found that 40% of umbilical cord blood lead levels exceeded the current internationally accepted level of harmful (100μg / L) .Based on umbilical cord blood lead levels were divided into high-lead group and lead group , Followed by a longitudinal follow-up of their body weight, length and head circumference at 3 months, 6 months and 12 months of life.Results In univariate analysis, we found that the body weight, Body height and head circumference are close to the mean difference between the only 3-month-old body weight difference was statistically significant.Analysis of covariance method were used to correct these factors, respectively, and then compare the high and low lead group differences found At 3 months of age, the body weight of children in high lead group lagged significantly behind that of children with low lead levels.Conclusion Lead exposure in fetus may have an adverse effect on the early physical growth of infants, but this effect may be covered by other factors in the short term It does not seem obvious.