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目的探讨乌灵胶囊治疗功能性消化不良(FD)伴焦虑抑郁症的临床疗效。方法选取2015年12月—2017年1月于安吉县人民医院收治的FD伴焦虑抑郁症患者70例,按照随机数字表法将所有患者分为试验组(n=36)和对照组(n=34)。试验组患者给予乌灵胶囊治疗,对照组给予安慰剂治疗,两组患者均持续用药12周。比较两组患者的临床疗效、治疗前及治疗后4、8、12周Nepean消化不良指数简表(NDI)症状评分、NDI生活质量评分,及治疗前后抑郁、焦虑医院焦虑抑郁量表(HAD)评分。结果试验组患者治疗总有效率高于对照组(P<0.01)。治疗前及治疗后4周,两组患者NDI症状评分、NDI生活质量评分比较,差异无统计学意义(P>0.05);治疗后8、12周,试验组患者NDI症状评分、NDI生活质量评分低于对照组(P<0.05)。治疗前,两组患者HAD抑郁评分、HAD焦虑评分比较,差异无统计学意义(P>0.05);治疗后,试验组患者HAD抑郁评分、HAD焦虑评分低于对照组(P<0.05)。结论采用乌灵胶囊治疗FD伴焦虑抑郁症的临床疗效确切,可有效改善患者的临床症状,降低焦虑、抑郁程度,提高患者的生活质量。
Objective To investigate the clinical efficacy of Wuling Capsule in the treatment of functional dyspepsia (FD) with anxiety and depression. Methods Seventy patients with FD and anxiety and depression admitted to People’s Hospital of Anji County from December 2015 to January 2017 were enrolled. All patients were divided into experimental group (n = 36) and control group (n = 34). Patients in the experimental group were treated with Wuling capsule, while those in the control group were treated with placebo. Patients in both groups continued to receive drugs for 12 weeks. The clinical efficacy, Nepan index (NDI) symptom score, NDI quality of life score before and after treatment were compared between the two groups before and after treatment, and depression before and after treatment, anxiety and depression scale (HAD) score. Results The total effective rate of treatment group was higher than that of control group (P <0.01). Before treatment and 4 weeks after treatment, NDI symptom scores and NDI quality of life scores of two groups had no significant difference (P> 0.05); NDI symptom scores, NDI quality of life scores Lower than the control group (P <0.05). Before treatment, HAD depression scores and HAD anxiety scores were not significantly different between the two groups (P> 0.05). After treatment, HAD depression scores and HAD anxiety scores in the experimental group were lower than those in the control group (P <0.05). Conclusion The clinical efficacy of Wuling capsule in treating FD with anxiety and depression is definite, which can effectively improve the clinical symptoms, reduce the anxiety and depression, and improve the quality of life of patients.