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用动物实验模拟快速房率来观察阻断迷走神经对心房有效不应期 (AERP)及其离散 (dAERP)的影响。用 8只杂种犬自身前后对照 ,观察阻断迷走神经张力不同状态下犬的AERP及dAERP的变化及其关系。结果 :① 80 0次/分的快速心房刺激很快引起AERP缩短 ,dAERP无明显变化。停止刺激后AERP恢复很快 ,dAERP明显升高。②刺激前单用阿托品阻断迷走神经 ,AERP和dAERP无明显变化 ,快速刺激仍能引起AERP缩短 ,刺激终止后dAERP升高不明显。③刺激前联用阿托品和普奈洛尔同时阻滞交感及迷走神经 ,AERP明显升高 ,dAERP无明显变化 ,快速刺激仍能引起AERP缩短 ,刺激终止后dAERP升高不明显。结论 :心房快速刺激时 ,阻断迷走神经不能阻止AERP的缩短 ,交感和迷走神经对快速刺激终止后的dAERP逐渐升高可能有作用
Animals were used to simulate rapid room rates to observe the effect of blocking the vagus nerve on atrial effective refractory period (AERP) and its discrete (dAERP). The changes of AERP and dAERP in dogs with different states of vagus nerve block and their relations were observed with 8 dogs before and after themselves. Results: (1) Atrial natriuretic peptide (80%) / min rapid atrial natriuretic stimulus shortened AERP quickly and no obvious change of dAERP. After stopping stimulation AERP recovery quickly, dAERP increased significantly. ② Before stimulation, atropine alone blocked the vagus nerve, and there was no obvious change in AERP and dAERP. AERP could still be shortened by rapid stimulation, but dAERP did not increase obviously after stimulation. ③ Before stimulation, atropine and propranolol blocked both sympathetic and vagal nerve, AERP was significantly increased, dAERP no significant change, rapid stimulation can still cause AERP shortening, dAERP increased after stimulation was not obvious. Conclusions: Blocking the vagus nerve can not prevent AERP shortening during rapid atrial stimulation, and sympathetic and vagal nerve may play a role in the gradual increase of dAERP after termination of fast stimulation