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本文总结了30例胆汁反流性胃炎(观察组)及13例无胆汁反流的浅表性胃炎(对照组)患者的空腹胃液 pH、酸度、Na~+、胆酸测定和胃粘膜屏障功能测定。观察组的空腹胃液胆酸为99.8±75.8μg/ml,Na+净流出量1.82±0.95mmol/15min,H~+分泌量7.47±5.44mmol/15min,H~+反弥散量-4.54±4.56mmol/15min,四者均显著高于对照组。空腹胃液胆酸定量可作为胆汁反流的客观指标。胆酸是一种胃粘膜屏障的损害因子,胆酸与 H~+逆弥散之间可能有因果关系。两组胃粘膜病理程度无显著差别,说明胃粘膜的保护机制较为复杂,进一步探讨这些机制,有利于探讨胆汁反流性胃炎新的防治途径。
This article summarizes fasting gastric juice pH, acidity, Na ~ +, bile acid determination and gastric mucosal barrier function in 30 cases of bile reflux gastritis (observation group) and 13 cases of superficial gastritis without bile reflux (control group) Determination. Fasting gastric juice bile acid in observation group was 99.8 ± 75.8μg / ml, net Na + efflux was 1.82 ± 0.95mmol / 15min, H ~ + secretion was 7.47 ± 5.44mmol / 15min, H ~ + anti dispersion was -4.54 ± 4.56mmol / 15min, four were significantly higher than the control group. Fasting gastric juice quantitative determination of bile reflux can be used as an objective indicator. Cholic acid is a gastric mucosal barrier damage factor, cholic acid and H ~ + inverse dispersion may have a causal relationship. There was no significant difference between the two groups in the pathological changes of gastric mucosa, indicating that the protective mechanism of gastric mucosa is more complicated. To further explore these mechanisms is conducive to explore new ways of prevention and treatment of bile reflux gastritis.