论文部分内容阅读
用ＨＰＭＣ为骨架材料，用湿法制粒，将易溶于水的盐酸雷尼替丁制成缓释骨架片，考察ＨＰＭＣ的用量、粘度、湿润剂的浓度，压片压力、片剂大小和亲水性及疏水性辅料对盐酸雷尼替丁缓释骨架片体外释药速率的影响。结果表明盐酸雷尼替丁缓释片的体外释放行为均符合Ｈｉｇｕｃｈｉ方程。ＨＰＭＣ用量、压片压力、片剂大小对盐酸雷尼替丁缓释片的释放速率均有显著性影响；ＨＰＭＣ粘度和用不同浓度乙醇制粒对盐酸雷尼替丁的释放速率影响不明显；亲水性辅料乳糖、ＰＶＰ－Ｋ３０和疏水性辅料ＥＣ加入均对释药速率有较大影响，前者加快药物释放而后者减慢药物释放
Using HPMC as the framework material, granulated by wet method, the ranitidine hydrochloride which is easily dissolved in water was made into a sustained-release matrix tablet, and the amount of HPMC, viscosity, concentration of wetting agent, tabletting pressure, tablet size and relatives Effect of aqueous and hydrophobic excipients on the in vitro release rate of ranitidine hydrochloride sustained release matrix tablets. The results showed that ranitidine hydrochloride sustained-release tablets in vitro release behavior in line with the Higuchi equation. HPMC dosage, tabletting pressure and tablet size had a significant effect on the release rate of ranitidine hydrochloride sustained-release tablets; the viscosity of HPMC and ethanol granulation with different concentrations had no obvious effect on the release rate of ranitidine hydrochloride; Hydrophilic excipients lactose, PVP-K30 and hydrophobic excipients EC have a greater impact on drug release rate, the former to speed up drug release and the latter slow drug release