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用F_w相关抗原单克隆抗体进行免疫组化染色,对48例肾细胞癌组织内血管分布密度进行定量分析。结果表明,在不同的组织构型中,随着组织学分级的增高,血管密度增高,组织学Ⅰ级为20.07±11.59个;组织学Ⅱ级为39.47±16.68个;组织学Ⅲ级为69.85±20.70个。每两组间的差异均有极显著意义(P<0.01)。在细胞类型方面,透明细胞癌为37.07±16.58个;颗粒细胞癌为30.64±23.76个;混合细胞型为37.01±28.40个;多形性细胞癌为64.83±15.06个。前三者之间的血管密度无显著差异(P>0.05),而多形性则与前三种类型之间均存在显著差异,(P值分别为<0.05,<0.05,<0.05),这与多形性未分化型肾细胞癌的恶性程度较高相吻合。同时结果提示血管密度与肾细胞癌的其它脏器的血行转移关系密切,可做为肾细胞癌预后的一个重要参考因素。
Immunohistochemical staining with F_w monoclonal antibody was used to quantitatively analyze the distribution of blood vessels in 48 cases of renal cell carcinoma. The results showed that in different histological configurations, with the increase of histological grade, the density of blood vessels increased, the histological grade Ⅰ was 20.07 ± 11.59, the histological grade Ⅱ was 39.47 ± 16.68, the histological grade Ⅲ was 69.85 ± 20.70. The difference between the two groups was significant (P <0.01). In terms of cell types, clear cell carcinoma was 37.07 ± 16.58; granulosa cell carcinoma was 30.64 ± 23.76; mixed cell type was 37.01 ± 28.40; and pleomorphic cell carcinoma was 64.83 ± 15.06. There was no significant difference in vascular density between the first three groups (P> 0.05), while polymorphism was significantly different from the first three types (P <0.05, <0.05, <0.05, respectively) And pleomorphic undifferentiated renal cell carcinoma consistent with the higher degree of malignancy. At the same time the results suggest that blood vessel density and renal cell carcinoma of other organs of blood metastasis is closely related to the prognosis of renal cell carcinoma as an important reference factor.